Pyridinium chloride → HCID 14365009, compound

HRID 1846482Notes

Reaction equation

HRID 1846482 reaction equation
[Cl:1][C:2]1[C:10]2[N:9]=[C:8]([CH3:11])[NH:7][C:6]=2[CH:5]=[CH:4][C:3]=1[O:12]C.Cl.N1C=CC=CC=1>>[Cl:1][C:2]1[C:10]2[N:9]=[C:8]([CH3:11])[NH:7][C:6]=2[CH:5]=[CH:4][C:3]=1[OH:12]

Participants

3

Reactant 2

HCID 10176127Pyridinium chlorideHCID 66978308HCID 66978308, compound

Product 1

HCID 14365009HCID 14365009, compound

Procedure

Under a nitrogen atmosphere 1.50 g (7.63 mmol) 4-chloro-5-methoxy-2-methyl-1H-benzo[d]imidazole and 11.20 g (0.10 mol) pyridine hydrochloride were stirred for 15 min at a bath temperature of 180° C. The reaction mixture was poured onto water while hot. The substance was extracted with ethyl acetate and washed with water. The organic phase was separated off, dried and evaporated down i.vac. The residue was stirred with DIPE and ethyl acetate, suction filtered and dried.

Workup

  1. additionThe reaction mixture was poured onto water while hot
  2. extractionThe substance was extracted with ethyl acetate
  3. washwashed with water
  4. customThe organic phase was separated off
  5. customdried
  6. customevaporated down i.vac
  7. filtrationfiltered
  8. customdried

Sources & evidence

ORD record
ord-112b1596cec847f8a4e3ccececc2db19
Source dataset
uspto-grants-2015_02
Patent number
US08952014B2

Reaction notes

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