HCID 21820480, compound → 4-Amino-5-methylbenzene-1,3-diol

HRID 1846485Notes

Reaction equation

HRID 1846485 reaction equation
[CH3:1][C:2]1[C:3]([N+:10]([O-])=O)=[C:4]([OH:9])[CH:5]=[C:6]([OH:8])[CH:7]=1.[H][H]>CO.[Pd]>[NH2:10][C:3]1[C:2]([CH3:1])=[CH:7][C:6]([OH:8])=[CH:5][C:4]=1[OH:9]

Participants

5

Reactant 2

HCID 21820480HCID 21820480, compoundHCID 178418361HCID 178418361, compound2×

Product 1

HCID 552817384-Amino-5-methylbenzene-1,3-diol

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

2.43 g (14.4 mmol) 5-methyl-4-nitrobenzene-1,3-diol were placed in 200 mL methanol and hydrogenated under a hydrogen atmosphere and with the addition of 0.20 g Pd/C (10%) at 50° C. and a hydrogen pressure of 5 bar until all the hydrogen had been taken up. The catalyst was filtered off and the filtrate was evaporated down i.vac.

Workup

  1. filtrationThe catalyst was filtered off
  2. customthe filtrate was evaporated down i.vac

Sources & evidence

ORD record
ord-579e0006bf16461680df601530657069
Source dataset
uspto-grants-2015_02
Patent number
US08952014B2

Reaction notes

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