HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acrolein dimer → {(3,4-Dihydro-2H-pyran-2-yl)-[1-(2-dimethylamino-ethyl)-1H-tetrazol-5-yl]-methyl}-(3-imidazol-1-yl-propyl)-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acrolein dimer | HCID 60994 | — |
| Reactant | Azidotrimethylsilane | HCID 78378 | — |
| Reactant | 1H-Imidazole-1-propanamine | HCID 78736 | — |
| Reactant | 2-Isocyano-N,N-dimethylethanamine | HCID 2771550 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | {(3,4-Dihydro-2H-pyran-2-yl)-[1-(2-dimethylamino-ethyl)-1H-tetrazol-5-yl]-methyl}-(3-imidazol-1-yl-propyl)-amine | HCID 25059390 | — |
Reaction Steps
3-Imidazol-1-yl-propylamine (1 mmol) and 3,4-Dihydro-2H-pyran-2-carbaldehyde (1 mmol) were combined in methanol (2 ml, dry). After 2 hours Trimethylsilylazide (5 mmol) and (2-Isocyano-ethyl)-dimethyl-amine (1 mmol) was added. The reaction was stirred at room temperature for 48 h. After evaporation of the solvent the residue was purified with chromatographic methods.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07741354B2 |
| Source dataset | uspto-grants-2010_06 |
| ORD ID | ord-859a5691f5d641a8b6aba2247b719733 |
| Source note | uspto-grants-2010_06 |