N-(4-(benzyloxy)-2-methyl-6-nitrophenyl)tetrahydro-2H-pyran-4-carboxamide → HCID 178428965, compound

HRID 1846504Notes

Reaction equation

HRID 1846504 reaction equation
C([O:8][C:9]1[CH:14]=[C:13]([N+:15]([O-])=O)[C:12]([NH:18][C:19]([CH:21]2[CH2:26][CH2:25][O:24][CH2:23][CH2:22]2)=O)=[C:11]([CH3:27])[CH:10]=1)C1C=CC=CC=1.[H][H]>C(O)(=O)C.[Pd]>[CH3:27][C:11]1[C:12]2[NH:18][C:19]([CH:21]3[CH2:26][CH2:25][O:24][CH2:23][CH2:22]3)=[N:15][C:13]=2[CH:14]=[C:9]([OH:8])[CH:10]=1

Participants

5

Reactant 2

HCID 66978329N-(4-(benzyloxy)-2-methyl-6-nitrophenyl)tetrahydro-2H-pyran-4-carboxamideHCID 178418361HCID 178418361, compound2×

Product 1

HCID 178428965HCID 178428965, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 176Acetic AcidSolvent

Procedure

0.33 g (0.84 mmol) N-(4-(benzyloxy)-2-methyl-6-nitrophenyl)tetrahydro-2H-pyran-4-carboxamide were placed in 10 mL acetic acid and hydrogenated under a hydrogen atmosphere and with the addition of 0.10 g palladium/charcoal (10%) at 50° C. and a hydrogen pressure of 5 bar until all the hydrogen had been taken up. The catalyst was filtered off and the filtrate was evaporated down i.vac.

Workup

  1. filtrationThe catalyst was filtered off
  2. customthe filtrate was evaporated down i.vac

Sources & evidence

ORD record
ord-432544f4a268432190f1d3e1f57a55fe
Source dataset
uspto-grants-2015_02
Patent number
US08952014B2

Reaction notes

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