反应详情

0.60 g (4.34 mmol) 3,4-diamino-5-methylphenol were placed in 2 mL acetic acid. 4.0 mL (0.03 mol) tetramethyl orthocarbonate were added and the mixture was stirred for 4 h at RT. The reaction mixture was purified by chromatography. The fractions containing product were combined and evaporated down i.vac. to leave the aqueous residue. This was neutralised with a 1M aqueous NaOH solution and extracted with ethyl acetate. The organic phase was dried and evaporated down i.vac.

1. customThe reaction mixture was purified by chromatography
2. additionThe fractions containing product
3. customevaporated down i.vac
4. customto leave the aqueous residue
5. extractionextracted with ethyl acetate
6. customThe organic phase was dried
7. customevaporated down i.vac