HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → 6-(6-chloro-2-trifluoromethyl-pyrimidin-4-yloxy)-4-methyl-3H-benzoxazol-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 2(3H)-Benzoxazolone, 6-hydroxy- | HCID 157167 | — |
| Reactant | 4,6-Dichloro-2-trifluoromethylpyrimidine | HCID 15713197 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 6-(6-chloro-2-trifluoromethyl-pyrimidin-4-yloxy)-4-methyl-3H-benzoxazol-2-one | HCID 86663928 | — |
Reaction Steps
0.40 g (1.86 mmol) 4,6-dichloro-2-trifluoromethylpyrimidine, 0.31 g (1.88 mmol) 6-hydroxy-2-benzoxazolinone and 0.28.g (2.03 mmol) potassium carbonate in 2.0 mL DMF were stirred for 2 h at RT. The reaction mixture was mixed with water and stirred for 1 h at RT. The precipitate formed was suction filtered, washed and dried.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08952014B2 |
| Source dataset | uspto-grants-2015_02 |
| ORD ID | ord-92379cd1e89f434898de727d40406b40 |
| Source note | uspto-grants-2015_02 |