Nitric Acid → N-[4-fluoro-2-nitro-6-(trifluoromethyl)phenyl]acetamide

Participants

Reaction Conditions

Reaction Steps

8.80 g (39.7 mmol) N-(4-fluoro-2-trifluoromethyl-phenyl)-acetamide were added to 60 mL 97% sulphuric acid while cooling with ice. 6.60 mL (95.3 mmol) nitric acid were slowly added dropwise to this mixture at 0° C. and with constant stirring. After the addition had ended the mixture was stirred for 30 min at 0° C. Then the cooling was removed and the reaction mixture was stirred for a further 1.5 h to complete the reaction. The reaction mixture was carefully poured onto 500 g ice and stirred for 30 min. The precipitate formed was filtered off, washed with 150 mL water and dried i. vac.

Provenance & Evidence