反应详情

温度

100 °C

A well stirred mixture of 3.00 g (11.2 mmol) N-(4-fluoro-2-nitro-6-trifluoromethyl-phenyl)-acetamide and 6.00 g (18.4 mmol) caesium carbonate in 90 mL methanol was heated for 10 min at 100° C. in the microwave. After cooling the solvent was eliminated i.vac. and the residue remaining was combined with 100 mL water. The aqueous phase was acidified with 10% citric acid and the product was extracted with 100 mL ethyl acetate. The organic phase was dried and evaporated down i.vac. The residue obtained was purified by flash chromatography. The fractions containing product were combined and evaporated down i.vac.

1. temperatureAfter cooling the solvent
2. extractionthe product was extracted with 100 mL ethyl acetate
3. customThe organic phase was dried
4. customevaporated down i.vac
5. customThe residue obtained
6. customwas purified by flash chromatography
7. additionThe fractions containing product
8. customevaporated down i.vac