HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-(4-methoxy-2-nitro-6-trifluoromethyl-phenyl)-acetamide → 6-methoxy-2-methyl-4-trifluoromethyl-1H-benzimidazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-(4-methoxy-2-nitro-6-trifluoromethyl-phenyl)-acetamide | HCID 66978303 | — |
| Reactant | HCID 178418361 | HCID 178418361 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | 6-methoxy-2-methyl-4-trifluoromethyl-1H-benzimidazole | HCID 66978213 | — |
Reaction Steps
A mixture of 0.55 g (1.98 mmol) N-(4-methoxy-2-nitro-6-trifluoromethyl-phenyl)-acetamide and 100 mg Pd/C in 30 mL acetic acid was hydrogenated for 5 h under a hydrogen atmosphere at 80° C. until all the hydrogen had been taken up. The catalyst was filtered off and the filtrate was evaporated down i.vac.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08952014B2 |
| Source dataset | uspto-grants-2015_02 |
| ORD ID | ord-33072e54c6cf498daf428f757eb2a836 |
| Source note | uspto-grants-2015_02 |