HuagongsheHuagongshe Chemistry Print Report · For research reference only
Pyridinium chloride → 2-methyl-7-trifluoromethyl-3H-benzimidazol-5-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Pyridinium chloride | HCID 10176127 | — |
| Reactant | 6-methoxy-2-methyl-4-trifluoromethyl-1H-benzimidazole | HCID 66978213 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 2-methyl-7-trifluoromethyl-3H-benzimidazol-5-ol | HCID 66978259 | — |
Reaction Steps
A well stirred mixture of 450 mg (1.95 mmol) 6-methoxy-2-methyl-4-trifluoromethyl-1H-benzimidazole and 2.50 g (21.6 mmol) pyridine hydrochloride was heated for 15 min to 200° C. After cooling to RT the reaction mixture was combined with 3.0 mL DMF and purified by preparative HPLC. The fractions containing product were combined and evaporated down i.vac.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08952014B2 |
| Source dataset | uspto-grants-2015_02 |
| ORD ID | ord-68c0fe24adfa46c5894f204c1205570c |
| Source note | uspto-grants-2015_02 |