Diisopropylethylamine → HCID 46244144, compound

Participants

Reaction Conditions

Reaction Steps

291 mg (1.00 mmol) 1-piperidin-4-yl-1,3-dihydroimidazo[4,5-b]pyridin-2-one-dihydrochloride, 276 mg (1.00 mmol) 4-chloro-6-(3,4-dimethyl-phenoxy)-pyrimidine and 0.697 mL (4.00 mmol) DIPEA were combined in 3.0 mL DMF and stirred for 4 h at 150° C. The reaction mixture was purified by preparative HPLC-MS. The product-containing fractions were combined, the acetonitrile was evaporated down and the residue was neutralised with 1N aqueous sodium hydroxide solution. The precipitate formed was suction filtered, washed with water and dried i. vac.

Provenance & Evidence