Diisopropylethylamine → HCID 46244318, compound

Participants

Reaction Conditions

Reaction Steps

70 mg (0.25 mmol) 7-methoxy-3-piperidin-4-yl-1,3,4,5-tetrahydro-1,3-benzodiazepin-2-one, 55 mg (0.20 mmol) (6-chloro-pyrimidin-4-yl)-(2,7-dimethyl-benzoxazol-5-yl)-amine and 0.15 mL (0.87 mmol) DIPEA were combined in 1.5 mL DMF and stirred for 2.5 h at 150° C. The reaction mixture was purified by preparative HPLC. The product-containing fractions were combined and freeze-dried. The residue was stirred with MeOH and DMF, left to stand for 1 h and filtered. The precipitate was washed with MeOH and dried.

Provenance & Evidence