HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → HCID 46244419, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 7-methoxy-3-(piperidin-4-yl)-4,5-dihydro-1H-benzo[d][1,3]diazepin-2(3H)-one | HCID 18356852 | — |
| Reactant | HCID 86663905 | HCID 86663905 | — |
| Solvent | N-methyl-2-pyrrolidone | HCID 13387 | — |
| Product | HCID 46244419 | HCID 46244419 | — |
Reaction Conditions
| Temperature | 130 °C |
|---|
Reaction Steps
187 mg (0.681 mmol) 7-methoxy-3-piperidin-4-yl-1,3,4,5-tetrahydro-1,3-benzodiazepin-2-one, 180 mg (0.490 mmol) 6-(6-chloro-pyrimidin-4-ylsulphanyl)-4-methyl-3H-benzoxazol-2-one and 200 mg (1.45 mmol) potassium carbonate were combined in 5.0 mL NMP and stirred for 2 h at 130° C. The reaction mixture was cooled overnight, filtered and the filtrate was purified by preparative HPLC. The product-containing fractions were combined, evaporated down and dried i. vac.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08952014B2 |
| Source dataset | uspto-grants-2015_02 |
| ORD ID | ord-6ea3f8de09ac45b493339719d85fa624 |
| Source note | uspto-grants-2015_02 |