Diisopropylethylamine → 6-{2-methoxy-6-[4-(7-methoxy-2-oxo-4,5-dihydro-1H-benzo[d][1,3]diazepin-3(2H)-yl)-piperidin-1-yl]pyrimidin-4-yloxy}-4-methylbenzo[d]oxazol-2(3H)-one

Participants

Reaction Steps

45 mg (0.16 mmol) 7-methoxy-3-piperidin-4-yl-1,3,4,5-tetrahydro-1,3-benzodiazepin-2-one, 50 mg (0.15 mmol) 6-(6-chloro-2-methoxypyrimidin-4-yloxy)-4-methylbenzo[d]oxazol-2(3H)-one and 0.10 mL (0.57 mmol) DIPEA in 1.0 mL DMF were stirred for 3 h at 90° C. The reaction mixture was purified by preparative HPLC-MS. The fractions containing product were combined and freeze-dried.

Provenance & Evidence