Water → 6-(2-cyclopropyl-6-(4-(7-methoxy-2-oxo-4,5-dihydro-1H-benzo[d][1,3]diazepin-3(2H)-yl)piperidin-1-yl)pyrimidin-4-yloxy)-4-methylbenzo[d]oxazol-2(3H)-one

Participants

Reaction Steps

39 mg (0.14 mmol) 7-methoxy-3-piperidin-4-yl-1,3,4,5-tetrahydro-1,3-benzodiazepin-2-one, 39 mg (0.12 mmol) 6-(6-chloro-2-cyclopropylpyrimidin-4-yloxy)-4-methylbenzo[d]oxazol-2(3H)-one and 0.10 mL (0.57 mmol) DIPEA in 1.0 mL DMF were stirred for 2 h at 90° C. The reaction mixture was mixed with water. The precipitate formed was suction filtered, washed and dried.

Provenance & Evidence