Water → HCID 46244852, compound

Participants

Reaction Steps

180 mg (0.65 mmol) 7-methoxy-3-piperidin-4-yl-1,3,4,5-tetrahydro-1,3-benzodiazepin-2-one, 205 mg (0.66 mmol) 6-(2,6-dichloropyrimidin-4-yloxy)-4-methylbenzo[d]oxazol-2(3H)-one and 0.25 mL (1.44 mmol) DIPEA in 5.0 mL DMF were stirred for 2 h at RT. The reaction mixture was mixed with water. The precipitate formed was suction filtered, washed and dried. The substance was purified by preparative HPLC-MS. The fractions containing product were partially evaporated down i.vac. and neutralised with sodium hydroxide solution. The precipitate formed was suction filtered, washed and dried.

Provenance & Evidence