Acetic Acid → HCID 46244938, compound

Participants

Reaction Steps

80 mg (0.17 mmol) 3-(1-(6-(4-amino-3-methylphenoxy)pyrimidin-4-yl)piperidin-4-yl)-7-methoxy-4,5-dihydro-1H-benzo[d][1,3]diazepin-2(3H)-one, 0.02 mL (0.35 mmol) AcOH, 120 mg (0.37 mmol) TBTU and 0.06 mL (0.43 mmol) TEA in 2.0 mL DMF were stirred for 2 h at RT. Water was added to the reaction mixture. The precipitate was suction filtered and purified by preparative HPLC-MS. The fractions containing product were combined and freeze-dried.

Provenance & Evidence