HCID 66978307, compound → HCID 178487202, compound

Participants

Reaction Steps

90 mg (0.17 mmol) 3-(1-(6-(4-chloro-2-methyl-1H-benzo[d]imidazol-5-yloxy)pyrimidin-4-yl)piperidin-4-yl)-7-methoxy-4,5-dihydro-1H-benzo[d][1,3]diazepin-2(3H)-one and 0.10 mL (0.71 mmol) TEA were placed in 10 mL methanol and hydrogenated under hydrogen atmosphere and with the addition of 10 mg Pd/C (10%) at 50° C. and a hydrogen pressure of 3 bar until the uptake of hydrogen had ended. The catalyst was filtered off and the filtrate was evaporated down i.vac. The residue was purified by preparative HPLC-MS. The fractions containing product were combined and freeze-dried.

Provenance & Evidence