Piperidine → HCID 67341377, compound

Participants

Reaction Steps

A mixture of 0.030 g (0.066 mmol) of N-(4-bromomethyl-5′-chloro-3,4,5,6-tetrahydro-2H-[1,2′]bipyridinyl-3′-yl)-3-chloro-benzamide, 0.028 g (0.033 mmol) of piperidine, and 0.10 mL (0.58 mmol) of N,N-diisopropylethylamine in acetonitrile (1 mL) is heated at 175 C in a microwave reactor for 30 minutes. The mixture is cooled to room temperature and purified by preparative reverse phase HPLC to give 0.001 g (3%) of the title compound (43) as a colorless solid. [M+H]+=461.2.

Provenance & Evidence