Ethanol → HCID 67341530, compound

Participants

Reaction Steps

A solution of 1.75 g (4.71 mmol) of (5′-methanesulfonyl-3′-nitro-3,4,5,6-tetrahydro-2H-[1,2′]bipyridinyl-4-yl)-acetic acid ethyl ester in a 1:1 mixture of ethanol:ethyl acetate (150 mL) is shaken over 1.0 g (0.94 mmol) of 10% palladium on carbon under an atmosphere of hydrogen overnight. The mixture is filtered through a pad of diatomaceous earth and concentrated under reduced pressure to provide 1.65 g (100%) of (3′-amino-5′-methanesulfonyl-3,4,5,6-tetrahydro-2H-[1,2′]bipyridinyl-4-yl)-acetic acid ethyl ester as a brown solid.

Provenance & Evidence