Carbon tetrabromide → HCID 67344867, compound

Participants

Reaction Conditions

Reaction Steps

To a mixture of 0.300 g (1.14 mmol) of triphenylphosphine, and 0.500 g (1.14 mmol) of 3-chloro-N-[4-(2-hydroxy-ethyl)-5′-methanesulfonyl-3,4,5,6-tetrahydro-2H-[1,2′]bipyridinyl-3′-yl]benzamide in methylene chloride (20 mL), cooled to 0° C., is added 0.380 g (1.14 mmol) of carbon tetrabromide in multiple portions. The mixture is warmed to room temperature and stirred overnight then concentrated under reduced pressure and the residue purified by flash silica gel chromatography to provide 0.285 g (50% yield) of N-[4-(2-bromo-ethyl)-5′-methanesulfonyl-3,4,5,6-tetrahydro-2H-[1,2′]bipyridinyl-3′-yl]-3-chloro-benzamide.

Provenance & Evidence