1-(2-Chloroethyl)piperidine → HCID 53307909, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 0.035 g (0.10 mmol) of 3-chloro-N-(5-chloro-2-piperazin-1-yl-pyridin-3-yl)-benzamide and 0.055 g (0.30 mmol) of 1-(2-chloroethyl)piperidine in acetonitrile (2 mL) is heated at 175° C. in a microwave reactor for 30 minutes. The mixture is cooled to room temperature and purified by preparative reverse phase HPLC to give 0.012 g (26%) of the title compound (107) as a brown oil. [M+H]+=464.2.

Provenance & Evidence