Hexahydro-1,4-diazepine → HCID 59548730, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 0.500 g (1.66 mmol) of 3-chloro-N-(2,5-dichloro-pyridin-3-yl)-benzamide and 0.498 g (4.97 mmol) of homopiperazine in acetonitrile (5 mL) is heated at 175° C. in a microwave reactor for 90 minutes. The mixture is cooled to room temperature and concentrated under reduced pressure. The residue is purified by flash silica gel chromatography to give 0.390 g (66.8%) of 3-chloro-N-(5-chloro-2-[1,4]diazepan-1-yl-pyridin-3-yl)-benzamide as a red oil.

Provenance & Evidence