Sodium Carbonate → HCID 67322286, compound

Participants

Reaction Steps

To 0.028 g (0.066 mmol) of N-(4-aminomethyl-5′-methanesulfonyl-3,4,5,6-tetrahydro-2H-[1,2′]bipyridinyl-3′-yl)-3-chloro-benzamide in a mixture of acetonitrile (0.5 mL) and saturated aqueous sodium carbonate (0.5 mL) is added 0.015 mg (0.079 mmol) of phenylmethanesulfonyl chloride. The mixture is stirred overnight at room temperature then diluted with water and extracted with ethyl acetate. The combined organic phase is washed with water, dried over anhydrous sodium sulfate and concentrated under reduced pressure. The residue is purified by preparative thin layer chromatography to give 0.027 g (72%) of the title compound (109) as a clear resin. [M+H]+=577.7.

Provenance & Evidence