Phenyl isocyanate → HCID 67323590, compound

Participants

Reaction Steps

To 0.028 g (0.066 mmol) of N-(4-aminomethyl-5′-methanesulfonyl-3,4,5,6-tetrahydro-2H-[1,2′]bipyridinyl-3′-yl)-3-chloro-benzamide in a mixture of acetonitrile (0.5 mL) and saturated aqueous sodium carbonate (0.5 mL) is added 0.0086 mL (0.11 mmol) of phenylisocyanate. The mixture is stirred at room temperature for 6 hours then concentrated under reduced pressure. The residue is diluted with water causing a gummy solid to form. The aqueous phase is decanted off and the solid is rinsed and decanted with water and then dried. The residue is purified by preparative thin layer chromatography to give 0.016 mg (44%) of the title compound (110) as a clear resin. [M+H]+=542.7.

Provenance & Evidence