1-(2-(Piperidin-4-yl)ethyl)piperidine → HCID 67321965, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 0.612 g (2.51 mmol) of 4-chloro-N-cyclopropyl-3-nitro-benzamide and 0.50 g (2.5 mmol) of 1-(2-piperidin-4-yl-ethyl)-piperidine in acetonitrile (0.5 mL) are heated at 110° C. for 30 minutes in a microwave reactor. The mixture is cooled to room temperature and concentrated under reduced pressure. The residue is purified by flash silica gel chromatography to provide 0.80 g (79%) of N-cyclopropyl-3-nitro-4-[4-(2-piperidin-1-yl-ethyl)-piperidin-1-yl]-benzamide.

Provenance & Evidence