Methanol → HCID 68304426, compound

Participants

Reaction Steps

To a solution of 0.115 g (0.241 mmol) of [3′-(3-chloro-benzoylamino)-5′-phenyl-3,4,5,6-tetrahydro-2H-[1,2′]bipyridinyl-4-yl]-acetic acid ethyl ester in a 5:2 mixture of tetrahydrofuran:methanol (7 mL) is added a solution of 0.028 g (1.2 mmol) of lithium hydroxide in water (1 mL). The reaction mixture is stirred at room temperature for 3 days and then concentrated under reduced pressure to remove volatile organics. The residue is diluted with water and the pH of the mixture is adjusted to approximately pH 2 by the addition of concentrated hydrochloric acid causing a solid to precipitate. The formed yellow solid is collected by filtration and dried under vacuum to provide 0.090 g (83%) of [3′-(3-chloro-benzoylamino)-5′-phenyl-3,4,5,6-tetrahydro-2H-[1,2′]bipyridinyl-4-yl]-acetic acid.

Provenance & Evidence