Hydrochloric Acid → HCID 67342749, compound

Participants

Reaction Conditions

Reaction Steps

To a mixture of 0.500 g (1.13 mmol) of 2-(5′-bromo-3′-nitro-3,4,5,6-tetrahydro-2H-[1,2′]bipyridinyl-4-yl)-1-(4-methyl-[1,4]diazepan-1-yl)-ethanone in water (25 mL) is added 1.0 g (17 mmol) of potassium hydroxide followed by 1.2 g (11 mmol) of sodium hydrosulfite. The mixture is heated at 60° C. for 4 hours then cooled to room temperature and the pH of the solution adjusted to neutral by the addition of a 2 N solution of hydrochloric acid. The mixture is extracted with a 3:1 mixture of methylene chloride:isopropanol and the combined organic phase is dried over anhydrous sodium sulfate and concentrated under reduced pressure to provide 0.261 g (56.0%) of 2-(3′-amino-5′-bromo-3,4,5,6-tetrahydro-2H-[1,2′]bipyridinyl-4-yl)-1-(4-methyl-[1,4]diazepan-1-yl)-ethanone.

Provenance & Evidence