Ethyl piperazine-1-acetate → HCID 67322758, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 5.00 g (16.6 mmol) of 3-chloro-N-(2,5-dichloro-pyridin-3-yl)-benzamide and 4.26 g (24.9 mmol) of piperazin-1-yl-acetic acid ethyl ester in a solvent free condition is heated to 105° C. and stirred for 20 hours. The residue is purified by flash silica gel chromatography to give 5.98 g (82.6%) of {4-[5-chloro-3-(3-chloro-benzoylamino)-pyridin-2-yl]-piperazin-1-yl}-acetic acid ethyl ester as a light yellow solid.

Provenance & Evidence