HCID 71238693, compound → HCID 68303889, compound

Participants

Reaction Steps

To a solution of 0.045 g (0.14 mmol) of (5′-cyano-3′-nitro-3,4,5,6-tetrahydro-2H-[1,2′]bipyridinyl-4-yl)-acetic acid ethyl ester in ethanol is added 0.015 g (0.0070 mmol) of 5% palladium on carbon. The mixture is placed under an atmosphere of hydrogen and stirred at room temperature overnight. The mixture is filtered through diatomaceous earth and concentrated under reduced pressure to give 0.043 g (95%) of (3′-amino-5′-cyano-3,4,5,6-tetrahydro-2H-[1,2′]bipyridinyl-4-yl)-acetic acid ethyl ester as a red oil.

Provenance & Evidence