Ethyl Acetate → HCID 67343145, compound

Participants

Reaction Steps

In a round bottom flask is placed 0.20 g (0.039 mmol) of 5% platinum sulfide on carbon. The vessel is evacuated and refilled with argon three times. To the flask is added a solution of 0.50 g (1.7 mmol) of 5′-chloro-3′-nitro-3,4,5,6-tetrahydro-2H-[1,2′]bipyridinyl-4-carboxylic acid methyl ester in a 1:1 mixture of ethyl acetate:methanol (30 mL). The mixture is placed under an atmosphere of hydrogen and stirred at room temperature overnight. The mixture is filtered through a pad of diatomaceous earth and concentrated under reduced pressure to provide 0.45 g (quant.) of 3′-amino-5′-chloro-3,4,5,6-tetrahydro-2H-[1,2′]bipyridinyl-4-carboxylic acid methyl ester as a dark oil.

Provenance & Evidence