HCID 67321994, compound → HCID 67323853, compound

Participants

Reaction Steps

To a solution of 0.800 g (2.49 mmol) of [1-(4-chloro-2-nitro-phenyl)-piperidin-4-yl]-acetic acid ethyl ester in ethanol (30 mL) is added 0.10 g (0.05 mmol) of 5% palladium on carbon. The mixture is placed under an atmosphere of hydrogen and stirred at room temperature overnight. The mixture is filtered through a pad of diatomaceous earth and concentrated under reduced pressure to provide 0.710 g (97.7%) of [1-(2-amino-4-chloro-phenyl)-piperidin-4-yl]-acetic acid ethyl ester as a dark foam.

Provenance & Evidence