Benzoyl chloride, 3-chloro- → HCID 68304434, compound

Participants

Reaction Steps

To a solution of 0.710 g (2.39 mmol) of [1-(2-amino-4-chloro-phenyl)-piperidin-4-yl]-acetic acid ethyl ester in acetonitrile (25 mL) is added 0.37 mL (2.9 mmol) of 3-chlorobenzoyl chloride. The mixture is stirred at room temperature for 2 hours then concentrated under reduced pressure. The residue is treated with a saturated aqueous solution of ammonium chloride and extracted with ethyl acetate. The combined organic phase is dried over anhydrous sodium sulfate and concentrated under reduced pressure. The residue is purified by flash silica gel chromatography to provide 0.590 g (56.7%) of {1-[4-chloro-2-(3-chloro-benzoylamino)-phenyl]-piperidin-4-yl}-acetic acid ethyl ester as a white solid.

Provenance & Evidence