Ethyl piperazine-1-acetate → HCID 68304438, compound

Participants

Reaction Conditions

Reaction Steps

A neat mixture of 0.500 g (2.54 mmol) of 3-amino-2-chloro-6-trifluoromethylpyridine and 0.870 g (5.09 mmol) of piperazin-1-yl-acetic acid ethyl ester is heated to 150° C. and stirred for 20 h. The mixture is cooled to room temperature, diluted with water, and extracted with ethyl acetate. The combined organic layer is washed with water followed by brine and then dried over anhydrous sodium sulfate and concentrated under reduced pressure. The crude material is purified by flash silica gel chromatography to provide 0.650 g (77.1%) of (3′-amino-6′-trifluoromethyl-3,4,5,6-tetrahydro-2H-[1,2′]bipyridinyl-4-yl)-acetic acid ethyl ester as a brown oil.

Provenance & Evidence