Tert-Butylamine → HCID 67341659, compound

Participants

Reaction Steps

A mixture of 0.100 g (0.226 mmol) of [3′-(3-chloro-benzoylamino)-6′-trifluoromethyl-3,4,5,6-tetrahydro-2H-[1,2′]bipyridinyl-4-yl]-acetic acid, 0.050 g (0.68 mmol) tert-butyl amine, 0.094 g (0.296 mmol) of O-(benzotriazol-1-yl)-N,N,N′,N′-tetramethyluronium tetrafluoroborate, and 0.094 mL (0.68 mmol) of triethylamine in N,N-dimethylformamide (2 mL) is stirred at room temperature for 2 hours. The mixture is diluted with water and purified using preparative reverse phase HPLC to give 0.020 g (18%) of the title compound (283) as colorless foam. [M+H]+=497.2.

Provenance & Evidence