Tert-Butylamine → HCID 67323405, compound

Participants

Reaction Steps

A mixture of 0.023 g (0.226 mmol) of [3′-(3-chloro-benzoylamino)-6′-methanesulfonyl-3,4,5,6-tetrahydro-2H-[1,2′]bipyridinyl-4-yl]-acetic acid, 0.011 g (0.15 mmol) of tert-butyl amine, 0.021 g (0.066 mmol) of O-(benzotriazol-1-yl)-N,N,N′,N′-tetramethyluronium tetrafluoroborate, and 0.021 mL (0.15 mmol) of triethylamine in N,N-dimethylformamide (2 mL) is stirred at room temperature for 2 hours. The mixture is diluted with water and purified using preparative reverse phase HPLC to give 0.016 g (62%) of the title compound (286) as colorless foam. [M+H]+=507.2.

Provenance & Evidence