Water → 1-(2-fluoro-4-nitrophenyl)-1H-pyrazole

Participants

Role	Name	HCID	Charge
Reactant	Water	HCID 962	—
Reactant	Pyrazole	HCID 1048	—
Reactant	Potassium Carbonate	HCID 11430	—
Reactant	1,2-Difluoro-4-nitrobenzene	HCID 123053	—
Solvent	Dimethylformamide	HCID 6228	—
Product	1-(2-fluoro-4-nitrophenyl)-1H-pyrazole	HCID 10703514	96.2%

Reaction Steps

A mixture of 3,4-difluoronitrobenzene (1.00 mL, 9.03 mmol), pyrazole (0.615 g, 9.04 mmol) and K2CO3 (2.50 g, 18.1 mmol) in DMF (10 mL) was stirred at room temperature overnight. Water (30 mL) was added to induce precipitation. The precipitate was collected, dried on vacuum to give 1-(2-fluoro-4-nitrophenyl)-1H-pyrazole as a solid (1.80 g). MS 208.3 (M+H)

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08952027B2
Source dataset	uspto-grants-2015_02
ORD ID	ord-e5899c4378e14c69b1439ed023788af3
Source note	uspto-grants-2015_02