HuagongsheHuagongshe Chemistry Print Report · For research reference only
Azidotrimethylsilane → 2-[[1-(2,2-Dimethyl-propyl)-1H-tetrazol-5-yl]-(3-imidazol-1-yl-propylamino)-methyl]-quinolin-8-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Azidotrimethylsilane | HCID 78378 | — |
| Reactant | 1H-Imidazole-1-propanamine | HCID 78736 | — |
| Reactant | 8-Hydroxy-2-quinolinecarboxaldehyde | HCID 599342 | — |
| Reactant | 1-Isocyano-2,2-dimethyl-propane | HCID 2758646 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 2-[[1-(2,2-Dimethyl-propyl)-1H-tetrazol-5-yl]-(3-imidazol-1-yl-propylamino)-methyl]-quinolin-8-ol | HCID 25060694 | — |
Reaction Steps
3-Imidazol-1-yl-propylamine (1 mmol) and 8-Hydroxy-quinoline-2-carbaldehyde (1 mmol) were combined in methanol (2 ml, dry). After 2 hours Trimethylsilylazide (5 mmol) and 1-Isocyano-2,2-dimethyl-propane (1 mmol) was added. The reaction was stirred at room temperature for 48 h. After evaporation of the solvent the residue was purified with chromatographic methods.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07741354B2 |
| Source dataset | uspto-grants-2010_06 |
| ORD ID | ord-3470187e804f4bbabac598a8116168a6 |
| Source note | uspto-grants-2010_06 |