Methanol → HCID 57471966, compound

HRID 1846734Notes

Reaction equation

HRID 1846734 reaction equation
[NH2:1][C@H:2]1[CH2:7][CH2:6][CH2:5][CH2:4][C@H:3]1[NH:8][C:9]1[N:14]=[C:13]([NH:15][C:16]2[CH:21]=[CH:20][CH:19]=[C:18](C3CCOCC=3)[CH:17]=2)[C:12]([C:28]([NH2:30])=[O:29])=[CH:11][N:10]=1.[CH3:31][OH:32]>[Pd]>[NH2:1][C@H:2]1[CH2:7][CH2:6][CH2:5][CH2:4][C@H:3]1[NH:8][C:9]1[N:14]=[C:13]([NH:15][C:16]2[CH:17]=[CH:18][C:19]([CH:2]3[CH2:3][CH2:4][O:32][CH2:31][CH2:7]3)=[CH:20][CH:21]=2)[C:12]([C:28]([NH2:30])=[O:29])=[CH:11][N:10]=1

Participants

4

Reactant 2

HCID 887MethanolHCID 57471963HCID 57471963, compound

Product 1

HCID 57471966HCID 57471966, compound

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

The title compound was prepared from Example 175 using standard catalysis hydrogenation by treating the solution of Example 175 in methanol with 10% Pd/C under H2 balloon for overnight. MS found for C22H30N6O2 as (M+H)+ 411.4. UV λ=243, 296 nm.

Sources & evidence

ORD record
ord-53560ed8ba844e6499cf40931f2e3430
Source dataset
uspto-grants-2015_02
Patent number
US08952027B2

Reaction notes

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