HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-(3,6-dihydro-2H-pyran-4-yl)-2-fluoropyridine → 2-Fluoro-3-(tetrahydro-2H-pyran-4-yl)pyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-(3,6-dihydro-2H-pyran-4-yl)-2-fluoropyridine | HCID 59326782 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 2-Fluoro-3-(tetrahydro-2H-pyran-4-yl)pyridine | HCID 59327155 | 95.3% |
Reaction Steps
To a solution of 3-(3,6-dihydro-2H-pyran-4-yl)-2-fluoro-pyridine (260 mg, 1.45 mmol) in MeOH (20 mL) was added Pd/C (0.1 g), bubbled with H2 and stirred at RT overnight. The reaction mixture was filtered and the filtrate was concentrated to give 2-fluoro-3-(tetrahydro-pyran-4-yl)-pyridine (250 mg, 1.38 mmol, 95.3% yield).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08952037B2 |
| Source dataset | uspto-grants-2015_02 |
| ORD ID | ord-43598cd280e240c5b31a983d7968cf0f |
| Source note | uspto-grants-2015_02 |