反应详情

温度

30 °C

A mixture of tert-butyl (3-((3-(3,6-dihydro-2H-pyran-4-yl)pyridin-2-yl)oxy)cyclobutyl)carbamate (346 mg, 1 mmol) and wet Pd—C (50%, 200 mg) in MeOH (100 mL) was stirred under H2 (40 psi) at 30° C. overnight then the reaction mixture was filtered through CELITE® and washed with MeOH. The filtrate was concentrated to give tert-butyl (3-((3-(tetrahydro-2H-pyran-4-yl)pyridin-2-yl)oxy)cyclobutyl)carbamate (331 mg, 0.95 mmol, yield 95%). ESI-MS (M+1): 349 calc. for C19H28N2O4 348.

1. filtrationthe reaction mixture was filtered through CELITE®
2. washwashed with MeOH
3. concentrationThe filtrate was concentrated