3-(3,6-Dihydro-2H-pyran-4-YL)-2,5-difluoro-pyridine → 2,5-Difluoro-3-(tetrahydro-pyran-4-YL)-pyridine

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Reaction Steps

To a solution of 3-(3,6-dihydro-2H-pyran-4-yl)-2,5-difluoro-pyridine (3.7 g, 18.8 mmol) in MeOH (40 mL) was added Pd/C (1.0 g). The reaction solution was stirred at RT overnight under H2 atmosphere until LCMS showed that the starting material was consumed completely. The mixture was filtered and the filtrate was concentrated to give the product (2.9 g, 78%).

Provenance & Evidence