Hydrochloric Acid → HCID 178521635, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of hydrogen chloride (5-6 N) in isopropyl alcohol (5 mL, 25 mmol), cis-benzothiazol-2-yl-(3-benzyloxy-cyclobutyl)-amine (500 mg, 1.6 mmol), and palladium black (250 mg, 50% wt percent) in EtOH (20 mL) under hydrogen atmosphere (balloon) was heated to 70° C. for 20 h. Then it was cooled to RT and solid NaHCO3 (500 mg) was added. The mixture was stirred until gas evolution ceased. The palladium was filtered off using Celite® and the filtrate was concentrated in vacuo to give oil (400 mg), which was used for next step without further purification.

Provenance & Evidence