Methanol → HCID 178511713, compound

Participants

Reaction Conditions

Reaction Steps

Palladium hydroxide (0.040 g, 0.057 mmol, 20 weight % on carbon) was added to a stirred mixture of trans-4-(3-(3,6-dihydro-2H-pyran-4-yl)pyrazin-2-yloxy)-N,N-bis(4-methoxybenzyl)cyclohexanamine (0.40 g, 0.77 mmol) in ethanol (4 mL). The reaction mixture was placed under a hydrogen atmosphere (balloon) and stirred at 50° C. for 18 h. Additional palladium hydroxide (0.040 g) and methanol (1 mL) were added, and the reaction mixture was stirred at 50° C. for an additional 5 h. The reaction mixture was filtered, and the filtrate was concentrated. The resulting crude product was purified via silica gel chromatography to give trans-4-(3-(tetrahydro-2H-pyran-4-yl)pyrazin-2-yloxy)cyclohexanamine as a colorless oil.

Provenance & Evidence