HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 4-methyl-N-(3-((3-(piperidin-4-yl)pyridin-2-yl)oxy)cyclobutyl)benzenesulfonamide hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Tert-butyl 4-(2-(3-(4-methylphenylsulfonamido)cyclobutoxy)pyridin-3-yl)piperidine-1-carboxylate | HCID 67481368 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 4-methyl-N-(3-((3-(piperidin-4-yl)pyridin-2-yl)oxy)cyclobutyl)benzenesulfonamide hydrochloride | HCID 67478729 | 95% |
Reaction Steps
To tert-butyl 4-(2-(3-(4-methylphenylsulfonamido)cyclobutoxy)pyridin-3-yl)piperidine-1-carboxylate (501 mg, 1 mmol) was added 4 M HCl in MeOH (100 mL). The solution was stirred at room temperature for 2 hours. The solvent was removed under reduced pressure to give 4-methyl-N-(3-((3-(piperidin-4-yl)pyridin-2-yl)oxy)cyclobutyl)benzenesulfonamide hydrochloride (381 mg, 0.95 mmol, yield 95%). ESI-MS (M+1): 402 calc. for C21H27N3O3S 401.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08952037B2 |
| Source dataset | uspto-grants-2015_02 |
| ORD ID | ord-b5025bf425d649559aafea7730d42a1a |
| Source note | uspto-grants-2015_02 |