{3-[5-(Tetrahydro-pyran-4-YL)-pyrimidin-4-yloxy]-cyclobutyl}-carbamic acid tert-butyl ester → 3-[5-(Tetrahydro-pyran-4-yl)-pyrimidin-4-yloxy]-cyclobutylamine

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Reaction Steps

The mixture of {3-[5-(tetrahydro-pyran-4-yl)-pyrimidin-4-yloxy]-cyclobutyl}-carbamic acid tert-butyl ester (1.2 g, 3.21 mmol) in HCl/MeOH (20 mL) was stirred at room temperature for 1 hour. Then it was concentrated to give 3-[5-(tetrahydro-pyran-4-yl)-pyrimidin-4-yloxy]-cyclobutylamine (916 mg, 3.21 mmol, yield: 93%) which was used in the next step without further purification. ESI-MS (M+1): 250 calc. for C13H19N3O2 249.

Provenance & Evidence