HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Chlorobenzenesulphonyl chloride → N-(5-Benzyloxy-4-oxo-4H-pyran-2-ylmethyl)-3-chloro-benzenesulfonamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Chlorobenzenesulphonyl chloride | HCID 17909 | — |
| Reactant | 2-Aminomethyl-5-benzyloxy-pyran-4-one | HCID 21524753 | — |
| Reactant | N-(5-benzyloxy-4-oxo-4H-pyran-2-ylmethyl)-benzene sulfonamide | HCID 86725690 | — |
| Product | N-(5-Benzyloxy-4-oxo-4H-pyran-2-ylmethyl)-3-chloro-benzenesulfonamide | HCID 86725722 | 56.92% |
Reaction Steps
N-(5-Benzyloxy-4-oxo-4H-pyran-2-ylmethyl)-3-chloro-benzenesulfonamide (7-05) (25.0 g, 56.92%) was synthesized as a brown solid from 2-aminomethyl-5-benzyloxy-pyran-4-one (5) (25 g, 108.22 mmol) and 3-chloro-benzenesulfonyl chloride (6-05) (22.98 mL, 162.33 mmol) following the procedure described for N-(5-benzyloxy-4-oxo-4H-pyran-2-ylmethyl)-benzenesulfonamide (7-01).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08952039B2 |
| Source dataset | uspto-grants-2015_02 |
| ORD ID | ord-8139112995414bdabd696c600c3dd8b0 |
| Source note | uspto-grants-2015_02 |