4-Chlorobenzenesulfonyl chloride → N-(5-Benzyloxy-4-oxo-4H-pyran-2-ylmethyl)-4-chloro-benzenesulfonamide

Participants

Role	Name	HCID	Charge
Reactant	4-Chlorobenzenesulfonyl chloride	HCID 7398	—
Reactant	2-Aminomethyl-5-benzyloxy-pyran-4-one	HCID 21524753	—
Reactant	N-(5-benzyloxy-4-oxo-4H-pyran-2-ylmethyl)-benzene sulfonamide	HCID 86725690	—
Product	N-(5-Benzyloxy-4-oxo-4H-pyran-2-ylmethyl)-4-chloro-benzenesulfonamide	HCID 86725737	56.92%

Reaction Steps

N-(5-Benzyloxy-4-oxo-4H-pyran-2-ylmethyl)-4-chloro-benzenesulfonamide (7-07) (20.0 g, 56.92%) was synthesized as a brown solid from 2-aminomethyl-5-benzyloxy-pyran-4-one (5) (20.0 g, 86.58 mmol) and 4-chloro-benzenesulfonyl chloride (6-07) (45.67 g, 216.45 mmol) following the procedure described for N-(5-benzyloxy-4-oxo-4H-pyran-2-ylmethyl)-benzenesulfonamide (7-01).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08952039B2
Source dataset	uspto-grants-2015_02
ORD ID	ord-2b79a383f9384e358ef7f1dfa330174c
Source note	uspto-grants-2015_02