HRID1846914

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：Cn1c(C(N)S(=O)(=O)c2ccccc2)cc(=O)c(O)c1C(=O)O

HCID86725697

未命名化合物

结构：CC(C)NC(=O)c1c(OCc2ccccc2)c(=O)cc(CNS(=O)(=O)c2ccc(Cl)cc2)n1C

HCID86725771

3-Benzyloxy-6-[(4-chloro-benzenesulfonylamino)-methyl]-1-methyl-4-oxo-1,4-dihydro-pyridine-2-carboxylic acid isopropylamide

C24H26ClN3O5S

PRODUCTS

生成物

结构：CC(C)NC(=O)c1c(O)c(=O)cc(CNS(=O)(=O)c2ccc(Cl)cc2)n1C

HCID86725772

未命名化合物

收率 50.8%

PROCEDURE

实验过程

6-[(4-Chloro-benzenesulfonylamino)-methyl]-3-hydroxy-1-methyl-4-oxo-1,4-dihydro-pyridine-2-carboxylic acid isopropylamide (18-07) (250.0 mg, 50.64%, purified by Prep-HPLC) was synthesized as an off white solid from 3-benzyloxy-6-[(4-chloro-benzenesulfonylamino)-methyl]-1-methyl-4-oxo-1,4-dihydro-pyridine-2-carboxylic acid isopropylamide (17-07) (600.0 mg, 1.19 mmol) following the procedure described for 6-(benzene sulfonyl amino-methyl)-3-hydroxy-1-methyl-4-oxo-1,4-dihydro-pyridine-2-carboxylic acid (14-01).