HuagongsheHuagongshe Chemistry Print Report · For research reference only
Lithium Hydroxide → HCID 58119001, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Lithium Hydroxide | HCID 3939 | — |
| Reactant | HCID 66849818 | HCID 66849818 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | HCID 58119001 | HCID 58119001 | 100% |
Reaction Steps
Methyl 4-(3-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)benzoate (12 mg) was dissolved in dioxane (1.5 mL). Lithium hydroxide (1 M in water, 0.5 mL) was added as one portion. After 24 h, quenched with 1N HCl. Extracted with dichloromethane, dried with MgSO4, and concentrated. Isolated 11 mg of 4-(3-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)benzoic acid (˜100%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08952034B2 |
| Source dataset | uspto-grants-2015_02 |
| ORD ID | ord-ca991209a03944f099a10223d34e8aca |
| Source note | uspto-grants-2015_02 |